Na+ spike amplitude and afterhyperpolarizing potential (AHP), respectively, measured from the reference voltage defined during the Na+ spike upstroke where dV/dt exceeds 5 V/s. CV, coefficient of variation of interspike intervals; –dV/dt and +dV/dt, peak magnitude of first time derivatives during upstroke and repolarization, respectively; HW, width of Na+ spike at ½ peak amplitude measured from the same reference voltage. *P < 0.05 compared with wild-type (WT).
Article: The leaner P/Q-type calcium channel mutation renders cerebellar Purkinje neurons hyper-excitable and eliminates Ca2+-Na+ spike bursts.
Full Text (publisher's website) ; Article Metadata ; Article Data (extracted) Ovsepian SV; Friel DD Eur. J. Neurosci., 2008
n | Peak (mV) | AHP (mV) | HW(ms) | –dV/dt(V/s) | +dV/dt(V/s) | CV | |
---|---|---|---|---|---|---|---|
WT | 17 | 66.2 ± 3.1 | 8.2 ± 1.1 | 0.42 ± 0.04 | 331 ± 9 | 288 ± 12.1 | 0.09 ± 0.02 |
tgla | 13 | 55.1 ± 2.7* | 3.8 ± 1.9* | 0.64 ± 0.04* | 230 ± 44* | 178 ± 16.3* | 0.18 ± 0.03* |
WT + ω-Aga-IVA | 6 | 54.2 ± 2.3* | 5.1 ± 1.2* | 0.54 ± 0.04* | 254 ± 15* | 237 ± 11* | 0.17 ± 0.02* |
Inferred neuron-electrophysiology data values
Neuron Type | Neuron Description | Ephys Prop | Extracted Value | Standardized Value | Content Source |
---|---|---|---|---|---|
Cerebellum Purkinje cell | spike peak (mV) | 66.2 ± 3.1 (17) | 66.2 (mV) | Data Table | |
Cerebellum Purkinje cell | AHP amplitude (mV) | 8.2 ± 1.1 (17) | 8.2 (mV) | Data Table | |
Cerebellum Purkinje cell | spike half-width (ms) | 0.42 ± 0.04 (17) | 0.42 (ms) | Data Table | |
Cerebellum Purkinje cell | spike max decay slope (V/s) | 331.0 ± 9.0 (17) | 331.0 (mV/ms) | Data Table | |
Cerebellum Purkinje cell | spike max rise slope (V/s) | 288.0 ± 12.1 (17) | 288.0 (mV/ms) | Data Table |